3-KAT: A Potential Drug Target for Energy Metabolism (P41842)

Target Name: 3-Ketoacyl-CoA Thiolase (3-KAT)

NCBI ID: P41842

Other Name(s): 3-Ketoacyl-CoA Thiolase | 3-KAT

3-KAT: A Potential Drug Target for Energy Metabolism

3-Ketoacyl-CoA Thiolase (3-KAT) is an enzyme that plays a crucial role in the metabolism of fatty acids and ketones. It is a key enzyme in the citric acid cycle, also known as the Krebs cycle or tricarboxylic acid (TCA ) cycle, which is responsible for generating energy in the form of ATP from the food we eat.

3-KAT is a protein that is expressed in most tissues of the body and is involved in the citric acid cycle. It is a subunit of the TCA cycle and is localized to the mitochondria. 3-KAT catalyzes the conversion of 3-ketoacyl- CoA (3-KAC) to 2-ketoglutarate (2-KET) via a series of intermediate steps.

The 3-KAT enzyme has been identified as a potential drug target in the field of metabolism and diseases. Its role in the TCA cycle makes it a promising target for interventions that target energy metabolism and the associated diseases, such as obesity, diabetes, and fatty liver diseases.

3-KAT has been shown to be involved in the regulation of energy metabolism and has been linked to the development and progression of several diseases. For example, 3-KAT has been shown to be involved in the development of obesity and non-alcoholic fatty liver disease (NAFLD).

In addition to its potential as a drug target, 3-KAT has also been shown to be a valuable biomarker for monitoring the progression of certain diseases. For example, the levels of 3-KAT have been shown to be elevated in the blood of obese individuals compared to those who are normal weight.

3-KAT has also been shown to be involved in the regulation of cellular signaling pathways. For example, 3-KAT has been shown to be involved in the regulation of the unfolded protein response (UPR), a signaling pathway that is involved in the regulation of protein structure and function.

In conclusion, 3-Ketoacyl-CoA Thiolase (3-KAT) is a protein that plays a crucial role in the metabolism of fatty acids and ketones. Its role in the TCA cycle makes it a promising target for interventions that target energy metabolism and the associated diseases. Its potential as a drug target and biomarker make it an attractive target for future research.

Protein Name: 3-Ketoacyl-CoA Thiolase (3-KAT) (nonspecified Subtype)

More Common Targets